Pharmaceutics, Free Full-Text
By A Mystery Man Writer
Last updated 07 Jun 2024
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality. Oxidation has been identified as a prevalent degradation mechanism under pharmaceutically relevant conditions. So far, a systematic stability comparison of both PSs under pharmaceutically relevant conditions has not been conducted and little is known about the dependence of oxidation on PS concentration. Here, we conducted a comparative stability study to investigate (i) the different oxidative degradation propensities between PS20 and PS80 and (ii) the impact of PS concentration on oxidative degradation. PS20 and PS80 in concentrations ranging from 0.1 mg⋅mL−1 to raw material were stored at 5, 25, and 40 °C for 48 weeks in acetate buffer pH 5.5 and water, respectively. We observed a temperature-dependent oxidative degradation of the PSs with strong (40 °C), moderate (25 °C), and weak/no degradation (5 °C). Especially at elevated temperatures such as 40 °C, fast oxidative PS degradation processes were detected. In this case study, a stronger degradation and earlier onset of oxidation was observed for PS80 in comparison to PS20, detected via the fluorescence micelle assay. Additionally, degradation was found to be strongly dependent on PS concentration, with significantly less oxidative processes at higher PS concentrations. Iron impurities, oxygen in the vial headspaces, and the pH values of the formulations were identified as the main contributing factors to accelerate PS oxidation.
Aps C Gj Kavita Font Download - Colaboratory
Pharmaceutics, Free Full-Text
Pharmaceutics, Free Full-Text
Pharmaceutical Services Flyer - PSDPixel
Ozeki Ng Sms Gateway Trial To Full Patched Cracked - Colaboratory
Top view of colorful tablets and capsule pills in blister packaging arrange with beautiful pattern. Pharmaceutical industry concept. Full frame pills background. Global pharmaceuticals. Defective. 7774187 Stock Photo at Vecteezy
Pharmaceutics, Free Full-Text
Pharmaceutics, Free Full-Text, thomas mitchell overton execution
Pharmaceutics, Free Full-Text
Pharmaceutics, Free Full-Text
115 Empty Pharma Capsules Stock Photos - Free & Royalty-Free Stock Photos from Dreamstime
PDF] Obtaining and providing health information in the community pharmacy setting.
Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar(R) / Prolopa(R). : Gasser, Urs E : Free Download, Borrow, and Streaming : Internet Archive
Recommended for you
-
Polysorbate 80, Thermo Scientific Chemicals07 Jun 2024
-
Polysorbate 80 t-maz 80 tween 80 solubilizer surfactant & emulsifier pure 7 lb07 Jun 2024
-
Polysorbate 80 T-MAZ 80 Tween 80 Surfactant Emulsifier07 Jun 2024
-
Polysorbate 80, Food Grade, From Kosher07 Jun 2024
-
Polysorbate 80, Tween 8007 Jun 2024
-
POLYSORBATE 80 NF07 Jun 2024
-
Polysorbate 80, Ingredient07 Jun 2024
-
Buy Tween 80 (Polysorbate 80)-nonionic Surfactant & Emulsifier For Food And Cosmetics From China Manufacturer And Factory07 Jun 2024
-
Mystic Moments Polysorbate 80 (Solubilser) - 125g07 Jun 2024
-
Structure of polysorbate 80.07 Jun 2024
You may also like
-
Black Walnut #6 – Meyer's Mill07 Jun 2024
-
Stanley 2 1991 Regular Duty Utility Blades with Dispenser - 11-911A07 Jun 2024
-
3D model Low poly - Cute Gift Box VR / AR / low-poly07 Jun 2024
-
5D Diamond Painting Small Village Kit - Bonanza Marketplace07 Jun 2024
-
Double Poppy flower pin: Crochet pattern07 Jun 2024
-
White Artificial Pearl Strands Spool Beads Roll Garland - Temu07 Jun 2024
-
Ampersand Museum Series Gessobord 2 Deep Cradled Panel, 10 x 20 - Box of 407 Jun 2024
-
Paper Take-Out Bags - Rope Handles - Rectangle - White - 6..5 x 7.5 - Small - 10 Count Box07 Jun 2024
-
Gradation Confetti Sticker – StarPOP shop07 Jun 2024
-
Sammy07 Jun 2024