Polysorbate, the Good, the Bad and the Ugly
By A Mystery Man Writer
Last updated 23 May 2024
Polysorbate (PS) refers to a family of amphipathic, nonionic surfactants that is derived from ethoxylated sorbitan or isosorbide (a derivative of sorbitol) esterified with fatty acids. Polysorbates, specifically polysorbate 20 (PS20) and polysorbate 80 (PS80), are the most widely used surfactants in biopharmaceutical formulations to prevent proteins from denaturation, aggregation, surface adsorption and flocculant formulation during thaw.
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